UbiQ 开发、制造和商业化基于泛素和泛素样蛋白的试剂。借助这些试剂，我们能够加速泛素领域的基础研究和药物发现。
Ubi, manufactures and commercializes reagents based onubiquitin and ubi proteins. With these reagents weenable and expedite fundamental research and drug discovery in theubiquitin field.
Ubi specific HTS assay reagents and conductedDUB-inhibitor screening programs for internal development.
Ubi drug discovery programs on ubiquitin(-like) cascadeinhibitors based on UbiQ’s Triple E platform. Ubi thisplatform, published in Nature Chemical Biology (2016), whichexploits a reacting group that specifically traps the E1, E2 and E3ubi enzymes. By adding this ‘hook’ onto ubiquitin itselfor onto a small molecule, it had become possible to monitor and/orblock the activity of dozens of enzymes involved in proteinubi specifically. Our first program based on our TripleE technology was conducted in Sumi, which developedmechanism-based covalent SUMOylation inhibitors, targetingnon-oncogene SUMO addicted Myc, Notch1 or mutant KRAS drivencancers.
背景介绍：
Biotin-Ahx-Ub-VME (UbiQ-054) 是一种有效的、不可逆的特异性去泛素化抑制剂酶 (DUB)，1 在 N末端用生物素标记。2 氨基己酸接头用于产生生物素和 Ub 蛋白之间的额外空间，用于有效访问生物素结合实体。
产品详情：
Biotin-Ahx-Ub-VME (human sequence, synthetic)
货号/UbiQ code : UbiQ-054
批次/Batch # : B26112012-001
规格/Amount : 50 ug, lyophilized powder
纯度/Purity : ≥95% by cation-chromatography and RP-HPLC
分子量/Mol. Weight : found 8944 Da, calc 8945 Da
保存/Storage : powder at −20°C, solution at −80°C. Please avoidmultiple freeze/thaw cycles
分销/Distributor：靶点科技
产品文献Literature：
(1) Misaghi et al. J. Biol. Chem. 2005, 280, 1512.
(2) de Jong et al. ChemBioChem 2012, 13, 2251.