Trifluoroacetic acid (TFA)

三氟乙酸的反应集中在其羧基上。三氟甲基是已知的稳定的结构，对几乎所有的氧化、还原和水解条件都是惰性的。是强有机酸，但三氟乙酸比强无机酸弱得多。使用三氟乙酸作为烯烃水合促进剂允许由烯烃合成醇，烯烃聚合、氧化或以其他方式被硫酸分解。三氟乙酸促进了广泛的反应，包括酯化、缩合和氧化。与通常的酸催化剂相比，它的优点是反应更平稳，分解更少。TFA 还在这些应用中提供了简单的处理和恢复。The reactions of trifluoroacetic acid arecentered on its carboxyl group. The trifluromethyl group is of themost stable structures known, being inert towards practically alloxidizing, reducing, and hydrolyzing conditions. Although a strongorganic acid, trifluoroacetic acid is considerably weaker thanstrong inorganic acids. The use of trifluoroacetic acid as anolefin hydration promoter permits the synthesis of alcohols fromolefins which are polymerized, oxidized, or otherwise decomposed bysulfuric acid. A wide range of reactions are promoted bytrifluroacetic acid including esterifications, condensations, andoxidations. Its advantages over the usual acid catalysts aresmoother reaction and less decomposition. TFA also offers easyhandling and recovery in these applications.

Applications

• Solvent

• Catalyst

• Reagent

• Water miscible

• Low boiling point reagent

• High dielectric constant

• Strong acidity

• Trifluoromethyl group

• Less oxidizing than sulfuric acid

• Inert toward practically all oxidizing, reducing andhydrolyzing conditions